Chronic intermittent toluene inhalation in adolescent rats alters behavioural responses to amphetamine and MK801
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چکیده
منابع مشابه
Chronic intermittent hypoxia alters ventilatory and metabolic responses to acute hypoxia in rats.
We determined the effects of chronic exposure to intermittent hypoxia (CIH) on chemoreflex control of ventilation in conscious animals. Adult male Sprague-Dawley rats were exposed to CIH [nadir oxygen saturation (SpO2), 75%; 15 events/h; 10 h/day] or normoxia (NORM) for 21 days. We assessed the following responses to acute, graded hypoxia before and after exposures: ventilation (V̇e, via baromet...
متن کاملToluene alters brainstem enkephalinergic system in rats.
Acute exposure to high doses of toluene can generate respiratory depression. However, neurotoxic mechanism of its action in the brainstem is not completely clear. In this work, acute, but not subchronic, exposure of rats to toluene increased leu-enkephalin immunostaining in several myelencephalic nuclei implicated in cardiorespiratory control. Due to the physiological role of enkephalins in the...
متن کاملAdolescent Toluene Inhalation in Rats Affects White Matter Maturation with the Potential for Recovery Following Abstinence
Inhalant misuse is common during adolescence, with ongoing chronic misuse associated with neurobiological and cognitive abnormalities. While human imaging studies consistently report white matter abnormalities among long-term inhalant users, longitudinal studies have been lacking with limited data available regarding the progressive nature of such abnormalities, including the potential for reco...
متن کاملChronic exposure to manganese alters brain responses to amphetamine: a pharmacological magnetic resonance imaging study.
The parkinsonian symptoms and increased Mn accumulation in dopaminergic (DAergic) neurons of the basal ganglia implicate impaired dopamine signaling in the neurotoxic effects of chronic manganese overexposure. Using blood oxygenation level-dependent (BOLD) pharmacological magnetic resonance imaging (phMRI), we mapped brain responses to acute amphetamine (AMPH; 3 mg/kg, ip), which stimulates mid...
متن کاملCranial MR findings in chronic toluene abuse by inhalation.
BACKGROUND AND PURPOSE Chronic abuse of toluene by inhalation causes variable white matter changes and thalamic hypointensity on T2-weighted MR images. The purpose of our study was to assess cranial MR findings in a large series of patients who chronically abuse toluene-containing solvents to investigate the factors causing the qualitative variability of white matter changes and thalamic hypoin...
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ژورنال
عنوان ژورنال: European Neuropsychopharmacology
سال: 2014
ISSN: 0924-977X
DOI: 10.1016/j.euroneuro.2013.06.001